泼尼?– 有机?/title> <atom:link href="//9my.com.cn/archives/tag/%E6%B3%BC%E5%B0%BC%E6%9D%BE/feed" rel="self" type="application/rss+xml" /> <link>//9my.com.cn</link> <description>有机?/description> <lastBuildDate>Tue, 22 Oct 2024 08:13:28 +0000</lastBuildDate> <language>zh-CN</language> <sy:updatePeriod>hourly</sy:updatePeriod> <sy:updateFrequency>1</sy:updateFrequency> <generator>//wordpress.org/?v=4.9.26</generator> <item> <title>泼尼?/title> <link>//9my.com.cn/archives/601</link> <pubDate>Mon, 03 Jun 2024 07:37:39 +0000</pubDate> <dc:creator><![CDATA[admin]]></dc:creator> <category><![CDATA[新闻中心]]></category> <category><![CDATA[泼尼松]]></category> <guid isPermaLink="false">//9my.com.cn/archives/601</guid> <description><![CDATA[l构?物竞~号 015T 分子?C21H26O5 分子?358.43 标签 泼尼杄, 17Α,21-二羟?1,4-孕甾二烯-3,11,20-三酮, L肾上腺皮质激? 脱氢可的? 强的? L可的? 1,4-Pregnadiene-17,21-diol-3,11,20-trione, 1-Corti ...]]></description> <content:encoded><![CDATA[<p> <img src="//staticv5.basechem.org/img/tupu/old/6fe45cc366dc4fb6b3773e678e588d92.gif" alt="泼尼杄构式"></p> <p>l构?/p> <table class="summary-table table table-striped table-bordered"> <col width="90" /> <tbody> <tr> <th scope="row">物竞~号</th> <td>015T</td> </tr> <tr> <th scope="row">分子?/th> <td>C21H26O5</td> </tr> <tr> <th scope="row">分子?/th> <td>358.43</td> </tr> <tr> <th scope="row">标签</th> <td> <p> (ping)尼杄,</p> <p> 17Α,21-二(chu)(nuo)?1,4-(ying)甾二(chu)-3,11,20-(juan)酮(sou),</p> <p>  L肾上()腺皮(lu)激(lian)(shang)?</p> <p> 脱氢可的?</p> <p> 强(hong)(shou)?</p> <p> L(hui)可的?</p> <p> 1,4-Pregnadiene-17(wei),21-diol-3,11,20-trione,</p> <p> 1-Cortisone,</p> <p> 17,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione,</p> <p> Dehydrocortisone</p> </td> </tr> </tbody> </table> <ul class="nav nav-tabs"> <li class="active"><a href="#bh">~号pȝ</a></li> <li><a href="#wx">物性数?/a></li> <li><a href="#dl">毒理学数?/a></li> <li><a href="#st">生态学数据</a></li> <li><a href="#fz">分子l构数据</a></li> <li><a href="#js">计算化学数据</a></li> <li class="dropdown pull-right"> <a href="" class="dropdown-toggle">更多 <span class="caret"></span></a></p> <ul class="dropdown-menu" role="menu"> <li><a href="#xz">性质与稳定?/a></li> <li><a href="#zc">贮存Ҏ</a></li> <li><a href="#hc">合成Ҏ</a></li> <li><a href="#yt">用?/a></li> </ul> </li> </ul> <h2 id="bh">~号pȝ</h2> <p><b>CASP</b>53-03-2</p> <p><b>MDLP</b>MFCD00003608</p> <p><b>EINECSP</b>200-160-3</p> <p><b>RTECSP</b>TU4154100</p> <p><b>BRNP</b>2065301</p> <p><b>PubChemP</b>24898748</p> <h2 id="wx">物性数?/h2> <p> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>1.<SPAN>       </SPAN></SPAN></SPAN><SPAN>性状Q白色或cȝ色结晶性粉末。无气味。略有持l性苦?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>2.<SPAN>       </SPAN></SPAN></SPAN><SPAN>密度Q?/SPAN><SPAN lang="EN-US">g/mL,25/4</SPAN><SPAN>℃）Q?/SPAN><SPAN> </SPAN><SPAN>未确?/SPAN><SPAN> <SPAN> </SPAN><SPAN lang="EN-US"></SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>3.<SPAN>       </SPAN></SPAN></SPAN><SPAN>相对蒸汽密度Q?/SPAN><SPAN lang="EN-US">g/mL,</SPAN><SPAN>I(hong)</SPAN><SPAN lang="EN-US">=1</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>4.<SPAN>       </SPAN></SPAN></SPAN><SPAN>熔点Q?/SPAN><SPAN lang="EN-US">º(lu)C</SPAN><SPAN>Q：</SPAN><SPAN lang="EN-US">233</SPAN><SPAN>?/SPAN><SPAN lang="EN-US">235</SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>5.<SPAN>       </SPAN></SPAN></SPAN><SPAN>沸点Q?/SPAN><SPAN lang="EN-US">ºC,</SPAN><SPAN>常压Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>6.<SPAN>       </SPAN></SPAN></SPAN><SPAN>沸点Q?/SPAN><SPAN lang="EN-US">ºC, 13.33kpa</SPAN><SPAN>Q：(xi)</SPAN><SPAN> <SPAN lang="EN-US"></SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>7.<SPAN>       </SPAN></SPAN></SPAN><SPAN>折射(dui)：</SPAN><SPAN> </SPAN><SPAN>未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>8.<SPAN>       </SPAN></SPAN></SPAN><SPAN>闪点Q?/SPAN><SPAN lang="EN-US">ºC</SPAN><SPAN>Q：(xi)</SPAN><SPAN> </SPAN><SPAN>未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>9.<SPAN>       </SPAN></SPAN></SPAN><SPAN>比旋光度Q?/SPAN><SPAN lang="EN-US">º, C=1, DIOXANE</SPAN><SPAN>Q：</SPAN><SPAN lang="EN-US">172</SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>10.<SPAN>    </SPAN></SPAN></SPAN><SPAN>自燃Ҏ引燃温度Q?/SPAN><SPAN lang="EN-US">ºC</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>11.<SPAN>    </SPAN></SPAN></SPAN><SPAN>蒸气(que)压()(zhi)</SPAN><SPAN lang="EN-US">kPa,25ºC</SPAN><SPAN>Q：</SPAN><SPAN> </SPAN><SPAN>未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>12.<SPAN>    </SPAN></SPAN></SPAN><SPAN>饱(bian)蒸气(que)压（</SPAN><SPAN lang="EN-US">kPa,60º(lu)C</SPAN><SPAN>Q(duo)(xi)</SPAN><SPAN> </SPAN><SPAN>未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>13.<SPAN>    </SPAN></SPAN></SPAN><SPAN>燃烧热（</SPAN><SPAN lang="EN-US">KJ/mol</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>14.<SPAN>    </SPAN></SPAN></SPAN><SPAN>临界温度Q?/SPAN><SPAN lang="EN-US">º(lu)C</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>15.<SPAN>    </SPAN></SPAN></SPAN><SPAN>临界压力Q?/SPAN><SPAN lang="EN-US">KPa</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>16.<SPAN>    </SPAN></SPAN></SPAN><SPAN>ҎQ辛?/SPAN><SPAN lang="EN-US">/</SPAN><SPAN>_分配pL的对数|未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>17.<SPAN>    </SPAN></SPAN></SPAN><SPAN>爆炸上限Q?/SPAN><SPAN lang="EN-US">%,V/V</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>18.<SPAN>    </SPAN></SPAN></SPAN><SPAN>爆炸下限Q?/SPAN><SPAN lang="EN-US">%,V/V</SPAN><SPAN>Q：未确?/SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>19.<SPAN>    </SPAN></SPAN></SPAN><SPAN>溶解性：</SPAN><SPAN lang="EN-US">1g</SPAN><SPAN>产品溶于U?/SPAN><SPAN lang="EN-US">150ml</SPAN><SPAN>、约(hai)</SPAN><SPAN lang="EN-US">200ml</SPAN><SPAN>氯仿Q微溶于甲醇、二氧六环，极微溶于水?/SPAN><SPAN lang="EN-US"></SPAN></P> </p> <h2 id="dl">毒理学数?/h2> <p> <SPAN lang="EN-US">1</SPAN><SPAN>、急性毒性：女hl口<SPAN lang="EN-US">TDLo</SPAN>Q?SPAN lang="EN-US">2400ug/kg/2D-I</SPAN>Q男人经?SPAN lang="EN-US">TDLo</SPAN>Q?SPAN lang="EN-US">857ug/kg</SPAN>Q男人经?SPAN lang="EN-US">LDLo</SPAN>Q?SPAN lang="EN-US">400ug/kg</SPAN>Q女?SPAN lang="EN-US">TDLo</SPAN>Q?SPAN lang="EN-US">113mg/kg</SPAN>Q?/SPAN><br /> <SPAN>   鼠腹腔<SPAN lang="EN-US">LD50</SPAN>Q?SPAN lang="EN-US">135 mg/kg</SPAN>Q小鼠皮?SPAN lang="EN-US">LD50</SPAN>Q?SPAN lang="EN-US">101 mg/kg</SPAN>Q小鼠肌?SPAN lang="EN-US">LD50</SPAN>Q?SPAN lang="EN-US">600 mg/kg</SPAN></SPAN><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US">2</SPAN><SPAN>、致癌性：大鼠腹腔<SPAN lang="EN-US">TDLo</SPAN>Q?SPAN lang="EN-US">860mg/kg/26W-I</SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US">3</SPAN><SPAN>、繁D毒性：(xi)雌性小(he)鼠皮?SPAN lang="EN-US">TDLo</SPAN>Q?SPAN lang="EN-US">24mg/kg</SPAN>Q?SPAN lang="EN-US">13-18</SPAN>天后受孕<SPAN lang="EN-US"></SPAN></SPAN></P><br /> <SPAN lang="EN-US">4</SPAN><SPAN>、致H变<SPAN lang="EN-US">microorganismsTEST</SPAN>pȝQ细?SPAN lang="EN-US">–</SPAN>鼠伤寒沙门氏菌：<SPAN lang="EN-US">3333ug/plate</SPAN>Q?/SPAN><br /> <SPAN>   H变<SPAN lang="EN-US">microorganismsTEST</SPAN>pȝQ细?SPAN lang="EN-US">–</SPAN>鼠伤寒沙门氏菌：<SPAN lang="EN-US">333ug/plate</SPAN>Q?SPAN lang="EN-US"></SPAN></SPAN> </p> <h2 id="st">生态学数据</h2> <p> 暂(yong) </p> <h2 id="fz">分子l构数据</h2> <p> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>1?SPAN>   </SPAN></SPAN></SPAN><SPAN>()尔折射率(jun)(xi)</SPAN><SPAN lang="EN-US">94.08</SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>2(mo)?SPAN>   </SPAN></SPAN></SPAN><SPAN>摩尔体积Q?/SPAN><SPAN lang="EN-US">m<SUP>3</SUP>/mol</SPAN><SPAN>Q：(xi)</SPAN><SPAN lang="EN-US">273.6</SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>3?SPAN>   </SPAN></SPAN></SPAN><SPAN>{张比容</SPAN><SPAN lang="EN-US">(90.2K)</SPAN><SPAN>Q?/SPAN><SPAN lang="EN-US">757.0</SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>4?SPAN>   </SPAN></SPAN></SPAN><SPAN>(chen)面张力(qian)</SPAN><SPAN lang="EN-US">(dyne/cm)</SPAN><SPAN>Q?/SPAN><SPAN lang="EN-US">58.5</SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>5?SPAN>   </SPAN></SPAN></SPAN><SPAN>极化?/SPAN><SPAN lang="EN-US">(10-24cm<SUP>3</SUP>)</SPAN><SPAN>Q?/SPAN><SPAN lang="EN-US">37.29</SPAN></P> </p> <h2 id="js">计算化学数据</h2> <p> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>1?SPAN>   </SPAN></SPAN></SPAN><SPAN>疏水参数计算参考|<SPAN lang="EN-US">XlogP</SPAN>Q：<SPAN lang="EN-US">1.5</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>2?SPAN>   </SPAN></SPAN></SPAN><SPAN>氢键供体数量()Q?SPAN lang="EN-US">2</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>3?SPAN>   </SPAN></SPAN></SPAN><SPAN>氢键(yang)受体数量Q(ben)?SPAN lang="EN-US">5</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>4(mo)?SPAN>   </SPAN></SPAN></SPAN><SPAN>(hong)旋(qi)化学键(yang)数量Q?SPAN lang="EN-US">2</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>5?SPAN>   </SPAN></SPAN></SPAN><SPAN>互变异构体数量：<SPAN lang="EN-US">27</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>6?SPAN>   </SPAN></SPAN></SPAN><SPAN>拓扑(rou)子(man)表面积Q(ben)?SPAN lang="EN-US">TPSA</SPAN>Q：<SPAN lang="EN-US">91.7</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>7?SPAN>   </SPAN></SPAN></SPAN><SPAN>重原子数量：<SPAN lang="EN-US">26</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>8?SPAN>   </SPAN></SPAN></SPAN><SPAN>表面电荷Q?SPAN lang="EN-US">0</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>9?SPAN>   </SPAN></SPAN></SPAN><SPAN>复杂度：<SPAN lang="EN-US">764</SPAN></SPAN><SPAN lang="EN-US"></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>10?/SPAN></SPAN><SPAN>同位素原子数量：<SPAN lang="EN-US">0</SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>11?/SPAN></SPAN><SPAN>定原子立构(ying)(juan)心数量Q?SPAN lang="EN-US">6</SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>12(mo)?/SPAN></SPAN><SPAN>不确定原子立构中心数量：<SPAN lang="EN-US">0</SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>13(mo)?/SPAN></SPAN><SPAN>定化学键立构中心数量：<SPAN lang="EN-US">0</SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>14?/SPAN></SPAN><SPAN>(juan)确定化学键(yang)(ku)()(ying)(juan)心数(ban)()Q?SPAN lang="EN-US">0</SPAN></SPAN></P><br /> <P class="MsoNormal" align="left"><SPAN lang="EN-US"><SPAN>15(mo)?/SPAN></SPAN><SPAN>׃h键单元数量：<SPAN lang="EN-US">1</SPAN></SPAN></P> </p> <h2 id="xz">性质与稳定?/h2> <p> 暂无(xi) </p> <h2 id="zc">贮存Ҏ</h2> <p> <P class="MsoNormal"><SPAN>(juan)(juan)要用于(lu)各种急性严(yue)(yue)细菌感(mo)，(juan)(juan)重q(pian)性疾(gu)(shan)(tuo)胶原(shi)性疾(gu)(shan)(tuo)U(wan)斑(deng)疮(mo)(quan)(quan)(bai)节性动脉周围炎{）(ji)Q(ben)(ben)风湿病(mo)(quan)(quan)(liang)湿性关节炎(mo)肾(fu)(fu)(shan)综合征Q(ben)(ben)严(yue)(yue)(cao)气(qi)(yu)喘()(mo)血(hao)板减少性癜、(quan)(quan)(lu)l胞减少(shan)、急性淋(chen)性白血(shan)、(huo)(huo)U肾(fu)(fu)(juan)(juan)(ju)(xuan)皮质功能(juan)(juan)全(shan)、(huo)(huo)脱性皮(liao)、(huo)(huo)皰(ban)(mo)(quan)(quan)l性皮(liao)、湿疹等(li)(mo)?/P></SPAN><SPAN lang="EN-US"></SPAN> </p> <h2 id="hc">合成Ҏ</h2> <p> <SPAN>以可(fei)松(jian)(juan)原料制得?/SPAN> </p> <h2 id="yt">用?/h2> <p> <SPAN><br /> <P class="MsoNormal" align="left"><SPAN>主要用于各种急性严重细菌感染，严重q敏性疾病，胶原性疾病（U斑狼疮、结节性动脉周围炎{）Q风湿病、类风湿性关节炎、肾病综合征Q严重支气管哮喘、血板减少性癜、粒l胞减少症、急性淋巴性白血病、各U肾上腺皮质功能不全症、剥脱性皮炎、天皰疮、神l性皮炎、湿疹等?/SPAN><SPAN lang="EN-US"></SPAN></P></SPAN> </p> <p> 扩展阅读<a href="//www.newtopchem.com/archives/category/products/page/91">//www.newtopchem.com/archives/category/products/page/91</a></br>扩展阅读<a 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