乙酸可的?– 有机?/title> <atom:link href="//9my.com.cn/archives/tag/%E4%B9%99%E9%85%B8%E5%8F%AF%E7%9A%84%E6%9D%BE/feed" rel="self" type="application/rss+xml" /> <link>//9my.com.cn</link> <description>有机?/description> <lastBuildDate>Tue, 22 Oct 2024 08:13:28 +0000</lastBuildDate> <language>zh-CN</language> <sy:updatePeriod>hourly</sy:updatePeriod> <sy:updateFrequency>1</sy:updateFrequency> <generator>//wordpress.org/?v=4.9.26</generator> <item> <title>可的?/title> <link>//9my.com.cn/archives/365</link> <pubDate>Tue, 23 Apr 2024 08:20:09 +0000</pubDate> <dc:creator><![CDATA[admin]]></dc:creator> <category><![CDATA[新闻中心]]></category> <category><![CDATA[乙酸可的松]]></category> <guid isPermaLink="false">//9my.com.cn/archives/365</guid> <description><![CDATA[l构?物竞~号 0135 分子?C23H30O6 分子?402.48 标签 醋酸可的? 可的N酔R, 醋酸孕酮, 皮质? 醋酸皮质? 孕甾-4-?17, 21-二醇-3,11,20-三酮-21-醋酸? 21-乙酰氧基-17, 基孕甾-4-?3,11,20-三酮, cortisone 21-ac ...]]></description> <content:encoded><![CDATA[<p> <img src="//staticv5.basechem.org/img/tupu/old/6235dc6b26904c8688925ddcdcf18d11.gif" alt="可的杄构式"></p> <p>l构?/p> <table class="summary-table table table-striped table-bordered"> <col width="90" /> <tbody> <tr> <th scope="row">物竞~号</th> <td>0135</td> </tr> <tr> <th scope="row">分子?/th> <td>C23H30O6</td> </tr> <tr> <th scope="row">分子?/th> <td>402.48</td> </tr> <tr> <th scope="row">标签</th> <td> <p> 醋酸(mie)可的?</p> <p>   可的(qing)N(juan)(yan)R,</p> <p> 醋酸(ying)酮,</p> <p> 皮质?</p> <p> (yue)酸皮质?</p> <p> (ying)甾(yi)-4-?17,</p> <p>  21-二醇-3,11,20-三酮-21-醋酸(yan)?</p> <p> 21-(cen)酰氧基-17,</p> <p>  (ti)(zeng)孕甾(yi)-4-?3,11,20-三酮,</p> <p> cortisone 21-acetate,</p> <p> 11-dehydro-17-hydroxycorticosterone acetate,</p> <p> 11-dehydro-17-hydroxycorticosterone-21-acetate,</p> <p> 17,21-dihydroxypregn-4-ene-3,11,20-trione acetat,</p> <p> Ȁ?/p> </td> </tr> </tbody> </table> <ul class="nav nav-tabs"> <li class="active"><a href="#bh">~号pȝ</a></li> <li><a href="#wx">物性数?/a></li> <li><a href="#dl">毒理学数?/a></li> <li><a href="#st">生态学数据</a></li> <li><a href="#fz">分子l构数据</a></li> <li><a href="#js">计算化学数据</a></li> <li class="dropdown pull-right"> <a href="" class="dropdown-toggle">更多 <span class="caret"></span></a></p> <ul class="dropdown-menu" role="menu"> <li><a href="#xz">性质与稳定?/a></li> <li><a href="#zc">贮存Ҏ</a></li> <li><a href="#hc">合成Ҏ</a></li> <li><a href="#yt">用?/a></li> </ul> </li> </ul> <h2 id="bh">~号pȝ</h2> <p><b>CASP</b>50-04-4</p> <p><b>MDLP</b>MFCD00003609</p> <p><b>EINECSP</b>200-006-5</p> <p><b>RTECSP</b>GM9140000</p> <p><b>BRNP</b>2067543</p> <p><b>PubChemP</b>24278306</p> <h2 id="wx">物性数?/h2> <p><p>1.     性状Q白色或cȝ色结晶性粉末，无气?/p> <p>2.  &nbsp;  密度Qg/mL,25/4℃）Q未()定</p> <p>3.     相对蒸汽密度Qg/mL,I气=1Q：未确?/p> <p>4.     熔点QºCQ：237-240 C?/p> <p>5.     沸点QºC,常压Q：未确?/p> <p>6.     沸点QºC,5.2kPaQ：未确?/p> <p>7.  &nbsp;  折(hua)率：(xi)212 (C=1, MeOH)</p> <p>8.     闪点QºCQ：(xi) 223</p> <p>9.     比()度Qº）Q[(wei)]25D+166</p> <p>10.   自燃Ҏ引燃温度QºCQ：未确?/p> <p>11.   蒸气压（kPa,25ºCQ：未确?/p> <p>12.   饱和蒸气压（kPa,60ºCQ：未确?/p> <p>13.   燃烧热（KJ/molQ：未确?/p> <p>14.   临界温度QºCQ：未确?/p> <p>15.   临界压力QKPaQ：未确?/p> <p>16.   ҎQ辛?_分配pL的对数|未确?/p> <p>17.   爆炸上限Q?,V/VQ：未确?/p> <p>18.   爆炸下限Q?,V/VQ：未确?/p> <p>19.   溶解性：(lian)确(yue)?/p> </p> <h2 id="dl">毒理学数?/h2> <p><p>1、急性毒性：(xi)鼠腹腔(chang)LD50Q?5 mg/kgQ?</p> <p>2、致畸性：(man)草芽孢杆菌(xuan)验Q? gm/L</p> <p>3、生D毒?/p> <p>大鼠口径TDLoQ母?00 mg/kgQ大鼠口径TDLoQ父?6mg/kgQ?/p> <p>(chan)鼠(qu)(guan)腔(chang)TDLoQ(ben)(ben)?00 mg/kgQ(ben)(ben)大鼠皮下TDLoQ(ben)(ben)?00 mg/kgQ(ben)(ben)怀(ying)?-8(chan)；(chan)鼠(qu)皮下TDLoQ(ben)(ben)?00 mg/kgQ(ben)(ben)怀(ying)?2-13(chan)；</p> <p>(chan)(chan)鼠(xiang)()TDLoQ(ben)?00mg/kgQ(ben)怀(ying)?2-15(chan)(chan)；(chan)(chan)鼠(xiang)()TDLoQ(ben)?00mg/kgQ(ben)怀(ying)?-17(chan)(chan)；(chan)(chan)鼠(xiang)()TDLoQ(ben)?00mg/kgQ(ben)怀(ying)?6-22(chan)(chan)；</p> <p>大鼠肠道TDLoQ?00 mg/kgQ怀?-14天；大鼠肠道TDLoQ?0 mg/kgQ怀?6-19?/p> <p>(fan)腹(gui)TDLoQ(ben)?82 mg/kgQ(ben)(shen)?3天；(fan)腹(gui)TDLoQ(ben)?00mg/kgQ(ben)(shen)?-11天；</p> <p>(hao)(fan)皮下TDLoQ(ben)(ben)?00 mg/kgQ(ben)(ben)(shen)(ying)?-12天；(hao)(fan)皮下TDLoQ(ben)(ben)?22 mg/kgQ(ben)(ben)(shen)(ying)?3；(hao)(fan)皮下TDLoQ(ben)(ben)?50 mg/kgQ(ben)(ben)(shen)(ying)?4天；</p> <p>鼠肌肉TDLoQ?00mg/kgQ怀?1-12天；鼠肌肉TDLoQ?6mg/kgQ怀?3天；鼠肌肉TDLoQ?00mg/kgQ怀?1-14?/p> <p>鼠肠道TDLoQ?00 mg/kgQ?/p> <p>狗肌肉TDLoQ?50 mg/kgQ?/p> <p>兔子肌肉(gan)TDLoQ(ben)?5 mg/kgQ(ben)兔子眼(la)睛TDLoQ(ben)?880 ug/kgQ(ben)?/p> </p> <h2 id="st">生态学数据</h2> <p><p>通常Ҏ(gui)是不危害的，(ren)(pan)无政府(ke)许(gao)Q勿材料排入周围环境?/p> </p> <h2 id="fz">分子l构数据</h2> <p><p> </p> <p>1?nbsp; ()尔(que)(ge)射率：(xi)103.75</p> <p>2?nbsp; 摩尔体积Qcm<sup>3</sup>/molQ(ben)：318.1</p> <p>3?nbsp; {(sui)比容Q?0.2KQ：858.0</p> <p>4?nbsp; 表面张力Q(ben)(ben)dyne/cmQ(ben)(ben)：52.8</p> <p>5?nbsp; 极化率（10-24cm3Q(duo)41.13</p> </p> <h2 id="js">计算化学数据</h2> <p><p>1?nbsp; 疏(qi)(hong)数(cong)算(hong)考|XlogPQ2.1</p> <p>2?nbsp; 氢键供体数(ban)Q(ben)?</p> <p>3?nbsp; 氢键受体数量()Q?</p> <p>4?nbsp; 可旋转化学键数量Q?</p> <p>5(mo)?nbsp; 互变(liao)(yong)体数量(xi)30</p> <p>6?nbsp; 拓扑分(gong)(man)性表面积Q(ben)TPSAQ(ben)：97.7</p> <p>7?nbsp; (yue)(ao)子(qi)(yue)(xi)(xi)29</p> <p>8?nbsp; 表面电(dian)Q?</p> <p>9?nbsp; (chan)杂度：827</p> <p>10?nbsp; 同(wu)(qin)素原子(qi)量：0</p> <p>11?nbsp; 定原(zeng)(ku)构(juan)心数量Q(ben)?</p> <p>12?nbsp; 不确定原(ying)立(xiu)构中心(xie)量：(xi)0</p> <p>13?nbsp; 定化学键立构中(jian)数量(xi)(xi)0</p> <p>14?nbsp; 不确定(ya)(yi)学键立构中心(ji)(suo)量Q(ben)?</p> <p>15(mo)?nbsp; (wei)׃(bian)h(huan)键单(wei)数量(xi)1</p> </p> <h2 id="xz">性质与稳定?/h2> <p><p>白色针状l晶或结晶性粉?丙酮)Q无气味。在I气中稳定。Mp239- 241℃，比旋光度[]<sup>20</sup><sub>D</sub>+164(0.5%Q丙?、[]<sup>23</sup><sub>D</sub>+169(氯仿)、[]<sup>25</sup><sub>D</sub>+208-+217((bang)氧六环(yi))Q(ben)(ben)本品的溶液?40nm波长处有大吸收。(yong)溶于氯仿(1Q(ben)(ben)?)Q(ben)(ben)溶(bang)丙?1Q(ben)(ben)?5)Q(ben)(ben)微溶于和，(ren)难(ju)(bang)水。(yong)品溶(bang)(yi)(su)黄色(huai)而无荧光((juan)醋酸(gao)(a)化可的松相区??/p> </p> <h2 id="zc">贮存Ҏ</h2> <p> (lang)光Q密(heng)存? </p> <h2 id="hc">合成Ҏ</h2> <p><p>1、用妊娠双烯醇酮l环氧化、沃氏氧化、霉菌氧化、铬酸氧化、溴化氢开环，雷尼镍催化脱溴、碘化ƈ乙酰氧基|换制得Q?/p> <p>2、(heng)醋(yan)(mie)孕甾双烯(tang)醇酮为原料(lei)(ren)(ren)依次l(zi)过(beng)(pin)化(pin)氧(ai)(chen)、(gui)(chou)(pin)氧(ai)(chen)、黑(lin)根菌()物(pin)化、铬酐(qi)(ai)(chen)得11-酮基-16Q(ben)?7(dui)氧(ai)(zhen)体酮，(ren)(ren)l(zi)氢溴(cuo)(mie)(liao)(dui)，(ren)(ren)(pin)化脱溴得可的松Q(ben)后(man)(yao)与(ya)反应，(ren)(ren)再与(ya)(tan)(pi)醋(yan)(mie)(hun)作(hu)()得_品Q(ben)后(man)重结晶(duo)得?/p> </p> <h2 id="yt">用?/h2> <p><p>()化研究Q(ben)肾上腺(fei)质(chuan)Ȁ(shang)类(bei)(bei)药物Q(ben)(han)有抗(liao)、抗q(ma)敏{作()；泼尼N(juan)酔R(fei)(qiao)(xiang)(cui)。(yong)wؓ(fu)抗炎剂(san)用于(zhi)疗肾上腺(fei)质(chuan)低(yi)能症类(bei)(bei)风(zhi)性关(qu)炎、风(e)病、红(hai)斑狼(lian)疮等病?/p> </p> <p> 扩展阅读//www.newtopchem.com/archives/44151</br>扩展阅读//www.newtopchem.com/archives/39736</br>扩展阅读//www.cyclohexylamine.net/thermal-catalyst-polyurethane-delayed-thermal-catalyst/</br>扩展阅读//www.cyclohexylamine.net/cas499-80-9/</br>扩展阅读//www.cyclohexylamine.net/cas-2273-43-0-monobutyltin-oxide-butyltin-oxide/</br>扩展阅读//www.bdmaee.net/wp-content/uploads/2022/08/MS-glue-special-catalyst-MS-glue-catalyst-paint-catalyst.pdf</br>扩展阅读//www.newtopchem.com/archives/44701</br>扩展阅读//www.bdmaee.net/wp-content/uploads/2022/08/37-3.jpg</br>扩展阅读//www.newtopchem.com/archives/966</br>扩展阅读//www.bdmaee.net/cas-33568-99-9/</br></p> ]]></content:encoded> </item> </channel> </rss>