β-雌二?– 有机?/title> <atom:link href="//9my.com.cn/archives/tag/%CE%B2-%E9%9B%8C%E4%BA%8C%E9%86%87/feed" rel="self" type="application/rss+xml" /> <link>//9my.com.cn</link> <description>有机?/description> <lastBuildDate>Tue, 22 Oct 2024 08:13:28 +0000</lastBuildDate> <language>zh-CN</language> <sy:updatePeriod>hourly</sy:updatePeriod> <sy:updateFrequency>1</sy:updateFrequency> <generator>//wordpress.org/?v=4.9.26</generator> <item> <title>β-雌二?/title> <link>//9my.com.cn/archives/380</link> <pubDate>Wed, 24 Apr 2024 09:10:20 +0000</pubDate> <dc:creator><![CDATA[admin]]></dc:creator> <category><![CDATA[新闻中心]]></category> <category><![CDATA[β-雌二醇]]></category> <guid isPermaLink="false">//9my.com.cn/archives/380</guid> <description><![CDATA[l构?物竞~号 013E 分子?C18H24O2 分子?272.38 标签 Ovocylin, Dihydroxyestrin, 雌甾-1,3,5-(10)-三烯-3β,17β-二醇, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3 ...]]></description> <content:encoded><![CDATA[<p> <img src="//staticv5.basechem.org/img/tupu/old/88c40e0699fb4fab8d0c615e14c73d30.gif" alt="β-雌二醇结构式"></p> <p>l构?/p> <table class="summary-table table table-striped table-bordered"> <col width="90" /> <tbody> <tr> <th scope="row">物竞~号</th> <td>013E</td> </tr> <tr> <th scope="row">分子?/th> <td>C18H24O2</td> </tr> <tr> <th scope="row">分子?/th> <td>272.38</td> </tr> <tr> <th scope="row">标签</th> <td> <p> Ovocylin,</p> <p> Dihydroxyestrin,</p> <p> (ban)甾-1,3,5-(10)-三(ling)(tang)-3β,17β-二醇,</p> <p>  1,3,5-Estratriene-3,17β-diol,</p> <p> 17β(wei)-Estradiol,</p> <p>   3,17β-Dihydroxy-1,3,5(10)-estratriene,</p> <p> Dihydrofolliculin,</p> <p> 雌素(bang)(yue)(jie)Q雌(guan)性二(lao)醇；求偶(bang)(yue)(jie)Q二(lao)(ti)基雌(shen)(lian)素(bo)Q雌(guan)甾二(lao)?</p> <p> 酶¯白质·?/p> </td> </tr> </tbody> </table> <ul class="nav nav-tabs"> <li class="active"><a href="#bh">~号pȝ</a></li> <li><a href="#wx">物性数?/a></li> <li><a href="#dl">毒理学数?/a></li> <li><a href="#st">生态学数据</a></li> <li><a href="#fz">分子l构数据</a></li> <li><a href="#js">计算化学数据</a></li> <li class="dropdown pull-right"> <a href="" class="dropdown-toggle">更多 <span class="caret"></span></a></p> <ul class="dropdown-menu" role="menu"> <li><a href="#xz">性质与稳定?/a></li> <li><a href="#zc">贮存Ҏ</a></li> <li><a href="#hc">合成Ҏ</a></li> <li><a href="#yt">用?/a></li> </ul> </li> </ul> <h2 id="bh">~号pȝ</h2> <p><b>CASP</b>50-28-2</p> <p><b>MDLP</b>MFCD00003693</p> <p><b>EINECSP</b>200-023-8</p> <p><b>RTECSP</b>KG2975000</p> <p><b>BRNP</b>1914275</p> <p><b>PubChemP</b>24278426</p> <h2 id="wx">物性数?/h2> <p><p>1.       性状Q白色或乳白色叶片状或针状结Ӟ溶液Q；无臭。在I气中稳?/p> <p>2. &nbsp; &nbsp;   (fen)度Qg/mL,25/4℃）Q未定(lei)</p> <p>3.       相对蒸汽密度Qg/mL,I气=1Q：未确?/p> <p>4.  &nbsp;    熔点QºCQ(duo)(xi)178-179 C(lit.)</p> <p>5.       沸点QºC,常压Q：未确?/p> <p>6.       沸点QºC, 5.2 kPaQ：未确?/p> <p>7.       折(hua)率：80.4 (C=1, Dioxane)</p> <p>8.       闪点QºCQ：未确?/p> <p>9.       比旋光Qº）Q未定</p> <p>10.    自燃Ҏ引燃温度QºCQ：未确?/p> <p>11.    蒸气压（kPa,25 ºCQ：未确?/p> <p>12.    饱和蒸气压（kPa,60 ºCQ：未确?/p> <p>13.    燃烧热（KJ/molQ：未确?/p> <p>14.    临界温度QºCQ：未确?/p> <p>15.    临界压力QKPaQ：未确?/p> <p>16.    ҎQ辛?_分配pL的对数|未确?/p> <p>17.    爆炸上限Q?,V/VQ：未确?/p> <p>18.    (ji)炸下限Q(ben)?,V/VQ(ben)：未确?9.    (jing)解性：易溶(han)(han)于，(ren)(jing)(duo)丙(dang)、氯ѝ二(pin)六(jia)(dui)和(nin)(bian)(han)(han)Ԍ(ren)微溶(han)(han)于植物aQ(ben)几()乎不(jing)(duo)(pin)? </p> <h2 id="dl">毒理学数?/h2> <p><p>急性毒性：</p> <p>(juan)要的(fan)Ȁ性媄(yu)：</p> <p>在皮肤上面：刺激皮肤和黏?/p> <p>在眼睛上面：刺激的媄响?/p> <p>(nie)敏(shan)作用Q没有已(yu)的敏(gan)影响?/p> </p> <h2 id="st">生态学数据</h2> <p><p>L注解</p> <p>水危害?Qd国规例）Q通过名单q行自我评估Q该物质Ҏ有极其危害的?/p> <p> 即(jiao)是小量不要让(xuan)(gui)触地下水(an)、(gui)(an)道或污水(an)pȝ(hun)?nbsp;</p> <p>即极其小(he)量(dai)产品渗入C(cen)会寚w(gui)()水(an)造成危险</p> <p>若无政府许可Q勿(deng)材料排(ma)入周围环境?/p> </p> <h2 id="fz">分子l构数据</h2> <p><p>1?nbsp; 摩尔折射率：79.50</p> <p>2?nbsp; 摩尔体积Qcm<sup>3</sup>/molQ：232.6</p> <p>3?nbsp; {(jiang)张(qu)(jiao)容Q?0.2KQ(duo)(xi)615.4</p> <p>4?nbsp; (chen)面(kui)张力Qd(dun)yne/cmQ：48.9</p> <p>5(mo)?nbsp; 极(huo)率（10-24cm3Q(duo)(xi)31.51</p> </p> <h2 id="js">计算化学数据</h2> <p><p>1.疏水(an)参数计算(cheng)参(ta)|XlogPQ?(zu)?/P></p> <p>2.氢键供体(suo)量:2</p> <p>3.氢键(yang)受体(suo)(ban):2</p> <p>4.可旋(lun)转化学键(suo)(ban)():0</p> <p>5.互变异(yong)体数?9</p> <p>6.(ma)扑分子极性表面积40.5</p> <p>7.(yue)(ao)子(qi)(yue)?20</p> <p>8.表面电荷:0</p> <p>9.复杂?382</p> <p>10.同位(qin)素原子数?0</p> <p>11.定(lei)(zha)子(dao)立构中心数量:5</p> <p>12.不确(yue)(ya)子立构中(fu)心数?0</p> <p>13.定化学(wen)立构(qiao)心(xie)?0</p> <p>14.不确定化学键立构中心(suo)(ban):0</p> <p>15.׃(bian)h键单元数(yue)?1</p> </p> <h2 id="xz">性质与稳定?/h2> <p> (ban)激(lian)(shang)(jie)(qing)(qing)(huan)用(ke)(ke)Q(ben)(han)()未成q女子能(shi)促ɽW(heng)二性征的发育和性器官的(qing)(qing)(yang)(yi)Ş(xi)(xi)(gong)(xiao)()(xi)(xi)年奛_(chong)Q(ben)(yue)保持(juan)述W(heng)二性征外，(ren)q能(shi)(huan)子宫内膜(weng)生一p(fei)d(hui)的变化，(ren)产生周期性月(kui)l。也(jian)(jian)(jian)(jie)(e)子宫和输(qin)的(qing)(qing)zd(hui)Q(ben)(han)ƈ增加子宫肌(han)催(hai)(shang)(jie)(qing)(qing)敏(qi)(qi)(qi)(zhuo)性。此外，(ren)(ban)激(lian)(shang)还(jian)(jian)(jian)(jie)(e)(bo)(nan)钙盐的(qing)(qing)沉积Q(ben)(han)(kun)(yi)(nan)闭(yang)，(ren)大剂量(qi)(qi)(qi)(jian)(jian)(jian)(jie)高血(wei)甘油三脂(xiao)(shu)(gang)Q(ben)(han)(zhi)(bi)h钠u(jiang)留。较(ji)大剂量(qi)(qi)(qi)(ban)激(lian)(shang)还(jian)(jian)(jian)作用下(xiao)(juan)脑-垂体p(fei)ȝ(hun)Q(ben)抑制促性腺(xuan)Ȁ(shang)及催^(shang)(jie)(qing)(qing)分泌Q(ben)(han)ƈ(jian)(jian)(jian)抵消雄(cheng)Ȁ(shang)(jie)(qing)(qing)(juan)要(huan)用(ke)(ke)? </p> <h2 id="zc">贮存Ҏ</h2> <p><p>本品(fen)封避光q燥(qi)存(mo)?/p> </p> <h2 id="hc">合成Ҏ</h2> <p><p>1.()雄()?4-?19-ȝ(hun)(ai)?3,17-二酮(sou)(sou)l(zi)(zi)溴(han)化在()(())2-?-(huan)引(zhi)入溴(han)Q然(zhi)后(yi)()(())4-乙基-2-()基吡啶存在()(())下(nai)溴化(yi)(pin)（消(mao)(guang)Q，(ren)()成2,4,6-(ban)甾三烯-19-ȝ(hun)(ai)?3,17-二酮(sou)(sou)Q(han)(ai)l(zi)(zi)高温裂解生成雌酚酮(sou)(sou)Q()而锂(yu)氢q(ma)原制得该品?/p> </p> <h2 id="yt">用?/h2> <p><p>1.雌二醇戊酔R、雌二醇甲酸酯的中间体?/p> <p>2.<span style="font-family:Arial">雌激素类药。(yao)于(yi)宫功能性出(chen)、(huo)发性闭l、(quan)l期l合征(huo)前列(guan)癌(qian){?/span></p> </p> <p> 扩展阅读//www.newtopchem.com/archives/44226</br>扩展阅读//www.bdmaee.net/wp-content/uploads/2022/08/-EG-33-triethylenediamine-in-EG-solution-PC-CAT-TD-33EG.pdf</br>扩展阅读//www.bdmaee.net/wp-content/uploads/2021/05/2-4.jpg</br>扩展阅读//www.newtopchem.com/archives/40316</br>扩展阅读//www.bdmaee.net/toyocat-daem-catalyst-tosoh/</br>扩展阅读//www.bdmaee.net/wp-content/uploads/2022/08/Polyurethane-rigid-foam-catalyst-CAS-15875-13-5-catalyst-PC41.pdf</br>扩展阅读//www.bdmaee.net/nt-cat-a-305-catalyst-cas1739-84-0-newtopchem/</br>扩展阅读//www.morpholine.org/category/morpholine/page/4/</br>扩展阅读//www.cyclohexylamine.net/reactive-catalyst-dabco-reactive-catalyst/</br>扩展阅读//www.bdmaee.net/lupragen-n100-catalyst-basf/</br></p> ]]></content:encoded> </item> </channel> </rss>